Alendronate


What is Alendronate Chemistry and Physiology Side Effects
Bisphosphonates Treatment Risedronate

Research into Alendronate

Despite having been used widely for over a decade, alendronate and similar bisphosphonate drugs continue to inspire quite a bit of scientific research.

Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study

Histomorphometric study of the alendronate and monofluorophosphate effect in rat bones

Coencapsulation of alendronate and doxorubicin in pegylated liposomes: a novel formulation for chemoimmunotherapy of cancer

Experimental osteonecrosis: development of a model in rodents administered alendronate

Earlier effect of alendronate in mouse metaphyseal versus diaphyseal bone healing

Osteoporosis Treatment May also Benefit Breast Cancer Patients

Bisphosphonate, Common Osteoporosis Medication, May Improve Survival In Breast Cancer Patients

Bisphosphonates for Osteoporosis — Where Do We Go from Here? - New England Journal of Medicine

A Randomized, Double Blind, Placebo-Controlled Trial of Alendronate Treatment for Fibrous Dysplasia of Bone

Alendronate may be chemopreventive against colon cancer

Stem Cell Method Developed to Increase Bone Strength

F.D.A. to Review Safety of Bisphosphonates - NY Times story from Sept 2011

Synovitis induced by alendronic acid can present as acute carpal tunnel syndrome - British Medical Journal

Adverse events, bone mineral density and discontinuation associated with generic alendronate among postmenopausal women previously tolerant of brand alendronate

Link between bisphosphonates and oesophageal cancer - BBC

Pharmacologic Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women

Alendronate increases risk of dental complications

Effects of antifracture drugs in postmenopausal, male and glucocorticoid-induced osteoporosis--usefulness of alendronate and risedronate.

The Cost-effectiveness of Therapy With Teriparatide and Alendronate in Women With Severe Osteoporosis

Spontaneous femoral shaft fracture after long-term alendronate.

Femoral strength in osteoporotic women treated with teriparatide or alendronate.

Effect of local delivery of alendronate on bone formation in bioactive glass grafting in rats

Alendronate-loaded microparticles for improvement of intestinal cellular absorption.

Differing effects of denosumab and alendronate on cortical and trabecular bone.

Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.

Teriparatide or alendronate in glucocorticoid-induced osteoporosis.

Adverse events, bone mineral density and discontinuation associated with generic alendronate among postmenopausal women previously tolerant of brand alendronate

Effects of alendronate and hormone replacement therapy, alone or in combination, on bone mass in postmenopausal women with osteoporosis: a prospective, randomized study

The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation

Once-monthly risedronate for postmenopausal osteoporosis

Bisphosphonates in the management of postmenopausal osteoporosis – optimizing efficacy in clinical practice

Protective effect of hypoxia on bisphosphonate-related bone cell damage.

Undertreatment of osteoporosis in the oldest old? A nationwide study of over 700,000 older people

Effects of risedronate on bone marrow adipocytes in postmenopausal women.

Research into Teriparatide

Superior Gains in Bone Mineral Density and Estimated Strength at the Hip for Romosozumab Compared with Teriparatide in Women with Postmenopausal Osteoporosis Transitioning from Bisphosphonate Therapy: Results of the Phase 3 Open-Label Structure Study.

Effects of Romosozumab Compared with Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women with Low Bone Mass.

Effect of Teriparatide on Bone Formation in the Human Femoral Neck.

Does Teriparatide Improve Femoral Neck Fracture Healing: Results From A Randomized Placebo-controlled Trial.

Teriparatide and denosumab combination therapy and skeletal metabolism.

Patients with prior vertebral or hip fractures treated with teriparatide in the Direct Assessment of Nonvertebral Fractures in Community Experience (DANCE) observational study.

Teriparatide Increases Bone Formation and Bone Mineral Density in Adult Women With Anorexia Nervosa

Therapy of Osteoporosis in Men with Teriparatide

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy.

Bifunctional bisphosphonates for delivering PTH (1-34) to bone mineral with enhanced bioactivity.

Effects of a single injection of teriparatide on bone turnover markers in postmenopausal women

Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH (1–34)] in postmenopausal osteoporosis

Antiresorptives overlapping ongoing teriparatide treatment result in additional increases in bone mineral density.

Femoral strength in osteoporotic women treated with teriparatide or alendronate.

Teriparatide Delivery via Wireless Microchip - this is pretty wild and could make it a lot easier for patients to take teriparatide. Work still needs to be done, but good news.

Bone health in patients with brain tumors. - University of Virginia study. Patients with brain cancer are susceptible to bone diseases and can be treated with the same drugs used for osteoporosis.

Biologicals in osteoporosis: teriparatide and parathyroid hormone in women and men.

Early responsiveness of women with osteoporosis to teriparatide after therapy with alendronate or risedronate. - A study of limited scope suggests that teriparatide may be less effective when patienrs have previously taken bisphosphonate drugs (alendronate or risedronate).

Orthopedic uses of teriparatide

Short-term teriparatide delivery and osseointegration: a clinical feasibility study - the effects of teriparatide on the osseointegration of titanium implants.

Could teriparatide treat arthritis? - UK's NHS

Prescription drug therapies for prevention and treatment of postmenopausal osteoporosis. - overview of medications used for osteoporosis. Concludes they are mostly safe.

 

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