Alendronate


What is Alendronate Chemistry and Physiology Side Effects
Bisphosphonates Treatment Risedronate

Glossary

Alendronate
A bisphosphonate sodium salt C4H12NNaO??7P ?23H2O used to inhibit bone resorption in the prevention and treatment of osteoporosis in postmenopausal women and Paget's disease of bone.
Bisphosphonates
A class of drugs that increase bone strength and density. Bisphosphonates inhibit osteoclasts cells which break down bony material and allow reabsorption of calcium to the bloodstream.
Osteoporosis
A disease in which the density and quality of bone are reduced. Healthy bone looks like a honeycomb when viewed under a microscope. When osteoporosis occurs, the holes and spaces in the honeycomb enlarge. As bones become more porous and fragile, the risk of fracture is increases.
Osteoclasts
A specialized bone cell that breaks down the mineral part of the bone, allowing for the deposition of new minerals and maintenance of bone strength. In healthy bone the rate of bone deposition and bone absorption equal each other so that bone mass remains constant. Osteoporosis can occur when osteoclast activity outperforms osteoblast activity so more bone is taken up rather than being laid down
Osteoblasts
Bone cells that produce and deposit the collagen fiber matrix that is needed for the development of new bone,
Osteopenia
A condition characterized by a decreased density of bone, defined as a bone mineral density T-score between -1.0 and -2.5. Sometimes considered a precursor to osteoporosis.
Osteomalacia
Osteomalacia means soft bones. Developmental problems with bone formation or with the bone building process cause osteomalacia.
Paget's Disease of the Bone
Chronic condition of characterized by disorder of the normal bone remodeling process. Also known as osteitis deformans. Affects older skeletal bone of adults. Bone remodeling keeps bone strong and maintains normal calcium levels in the blood. In bone affected by Paget's disease, one or more localized areas are affected by abnormal bone remodeling. As a result, the bone that is formed is enlarged, brittle, and prone to fracture.
Osteonecrosis of the jaw
A condition in which an area of jawbone is not covered by the gums. The condition must last for more than eight weeks to be called ONJ. When the bone is left uncovered, it does not receive blood and begins to die. A rare side effect of alendronate.
Uveitis
Condition when the middle layer of the eyeball becomes inflamed. Uveitis can damage vital eye tissue, leading to permanent vision loss.
Scleritis
A disorder in which the sclera (protective outer layer of the eye) becomes severely inflamed and red. It can be very painful.
Risedronate
A sodium bisphosphonate salt C7?H?10?NNaO?7?P?2? taken orally to inhibit? bone resorption, alters bone formation and breakdown in the body, thus slowing the progression of bone loss.

 

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